Associate Scientist, Cell Therapy Process Development
AstraZeneca

About AstraZeneca in Gaithersburg, MD:

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most ground breaking technology and lab spaces, all designed to inspire collaboration and multi-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while growing collaboration between teams.

Main Duties & Responsibilities:

This position will involve performing experiments to design, optimize, characterize, and scale up consistent CAR-T cell processes. In this role you will implement cell therapy experiments and projects through multi-functional interactions with Research, Analytical Development, and other functions.

Key Responsibilities:

• Designs and performs laboratory experiments with guidance from senior team members to develop and optimize CAR-T cell processes.

• Makes detailed observations, analyses data, and interprets results. Demonstrates scientific rigor in assessing own data and that of others. Utilized forward-looking perspective to contribute to decision making.

• Familiar with different analytical methods that are used to characterize T cell proliferation and phenotype.

• Authors and contributes to development reports, scientific publications, patents, and regulatory submissions.

• Effectively presents results at internal meetings and external scientific meetings.

• Works effectively and collegially as a team member within a highly matrixed organizational structure.

Education & Experience Requirements:

Education: Bachelor's or Master's in Chemical/Biochemical/Biomedical Engineering, Biotechnology, Biochemistry, Biological Sciences, or related field

Associate Scientist: BS/MS and 0+ years of experience

Required Skills:

• Strong background in mammalian cell culture

• Experience with use and solving of cell processing using common platforms

• Excellent partnership and interpersonal skills including shown technical writing skills, good publication records

• Strong background in experimental design and data analysis skills.

• Ability to learn and adopt new technologies quickly, work independently, multi-task, and lead shifting priorities.

Desired Skills:

• Cell production and cell scale-up technology experience.

• Analysis of cell characteristics and phenotype using flow cytometry-based instruments and data analysis programs.

• Experience running experiments using DOE principle

• Understanding of biology and bioprocessing supporting adoptive cellular immunotherapy as a therapeutic modality desired.

• Uses knowledge of immunology, cellular engineering, T cell biology, T cell therapy, and bioprocess engineering and exhibits extensive experience working with multiple gene delivery systems for immune cells.

• Skills applicable to scale up and scale down of CAR-T processes and sophisticated analysis of flow cytometry data.

Why AstraZeneca?

At AstraZeneca, we seize opportunities for change, recognizing their potential to drive significant advancements. Our mission to deliver life-changing medicines is fueled by ambition-finding those moments that can lead to extraordinary outcomes. Join us on our journey to redefine what a biopharmaceutical company can be. We are pioneering innovative methods and bringing together diverse teams to achieve our goals.

Where can I find out more?

Our social media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

Competitive remuneration and benefits apply

We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We have a generous paid time off program and a comprehensive benefits package.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform crucial job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

The annual base pay (or hourly rate of compensation) for this position ranges from $66,766 - $100,149.60 USD, either as annual base pay or as the hourly rate (annual base pay divided by 2080 hours)]. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an "at-will position" and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.